The Ice3 trial - Cryoablation of low-risk
breast cancer

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AboutICE3 Trial

ICE3 is the largest controlled multilocation clinical trial ever performed for liquid nitrogen (LN2) based cryoablation of small, low-risk, early-stage malignant breast tumors without subsequently removing them. The trial began in 2014 and has completed recruitment of 206 patients in 19 hospitals and medical centers across the US, including Columbia University Medical Center and Mount Sinai Beth Israel.

ICE3 Trial promising interim results

Based on interim analysis performed in july 2022



Eligible Patients for Cryoablation



(Including Columbia University Medical Center and Mount Sinai Beth Israel)


Patients Followed For 5 Years*

*As of July 2022


ICE3 trial interim RESULTS


Recurrence Free as of July 2022

188 out of the 194 eligible patients did not have recurrence



Safe Procedure

No significant device-related adverse events or complications have been reported


Doctor Satisfaction
with Cosmetic Results


Patient Satisfaction
with Cosmetic Results

No scarring or change to the shape and size of the breast

Read the full ASBrS Press Release: “Freezing Cancer: Cryoablation Emerging as an Effective Treatment of Low Risk Breast Cancers – Three-year results of the ICE3 Trials”

What Medical Experts Are
Saying About Cryoablation

“Cryoablation potentially represents a dramatic improvement in care for appropriate low-risk patients, and at three years post-treatment, the ICE3 trial results are extremely positive. The noninvasive procedure is fast, painless and can be delivered under local anesthesia in a doctor’s office. Recovery time is minimal and cosmetic outcomes are excellent with little loss of breast tissue and no scarring. Now, this trial is underscoring the efficacy and safety of the procedure for this patient group.”

Richard E. Fine, MD, FACS, Director of Education and Research and practicing breast surgeon at West Cancer Center’s Comprehensive Breast Center, TN and ICE3 Investigator

Cryoablation Treatment

ProSense™ is commercially available in the US, Europe, Hong Kong, Thailand, Singapore, Central America and South America.

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