Scientific Support for Cryoablation

 

IceCure Medical is committed to the advancing research into the use of IceSense3 cryoablation for breast cancer. We believe it is a viable alternative to surgery for the treatment of some breast cancers.

We are currently enrolling patients in the landmark, multi-center ICE3 trial, where certain breast cancers will be cryoablated, then followed. No Surgery. We also support investigator-initiated studies at various academic institutions around the globe, including Kameda and St. Johns.

Because it utilizes the more advanced IceSense3 cryoablation system with low, stable, cryo temperatures, ICE3 has the potential to completely ablate tumors up to 1.5 cm.

Target Population

Our clinical trial will recruit and follow-up on women aged 65 years or older diagnosed with luminal A breast carcinoma whose tumors measure less than 1.5 centimeters in diameter. These patients will also receive adjunctive therapy based on local standards of care.

Study Design

The trial was crafted by a diverse and esteemed scientific advisory board will be conducted at 20 carefully selected sites throughout the United States and utilize IceSense3 consoles already installed for the treatment of fibroadenomas. As a market leader in cryoablation treatment of fibroadenomas, we will utilize our resources to provide clinical and technological support to sites.

Anticipated Benefits

The benefits of utilizing cryoablation to treat breast disease versus the historical treatment of excision or mastectomy are numerous. Cryoablation can be performed in a physician’s office with use of local anesthetic and ultrasound. Additionally, because no tissue is removed, there is minimal cosmetic impact with little to no scarring or permanent disfigurement. Further, cryoablation is an economically sound alternative to costly surgery.

Additional Studies

Simmons, R. Abstract Title: A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072.

Sabel MS, Su G, Griffith KA et al. Rate of Freeze Alters the Immunologic Response After Cryoablation of Breast Cancer. Annals of Surgical Oncology; Vol.17 Issue 4, Apr. 2009.

Trial Locations

The following locations are actively recruiting patients for the ICE3 trial.

California
Breastlink-Laguna Hills
Laguna Hills, CA 92653
Principal Investigator: Lisa Curcio, MD

Connecticut
Northeast Medical Group
Trumbull, Connecticut 06611
Principal Investigator: Andrew Kenler, MD

Georgia
Dalton Surgical Group
Dalton, GA 30720
Principal Investigator: Eric Manahan, MD

Indiana
Indiana University-Simon Cancer Center
Indianapolis, IN 46202
Principal Investigator: Linda Han, MD

Michigan
Comprehensive Breast Care
Troy, MI 48085
Principal Investigator: Linsey Gold, MD

Michigan
Karmanos Cancer Institute
Detroit, MI 48201
Principal Investigator: Hussein Aoun, MD

Michigan
Regional Medical Imaging
Flint, Michigan, 48507
Principal Investigator: Randy Hicks, MD

New Jersey
CentraState Medical Center
Freehold, New Jersey, 07728
Principal Investigator: Kenneth Tomkovich, MD

New Mexico
Breast Specialty Care
Albuquerque, NM 87114
Principal Investigator: Susan Seedman, MD

New York
Beth Israel Comprehensive Cancer Center
New York, NY 10011
Principal Investigator: Susan Boolbol, MD/ Sarah Cate, MD

New York
Columbia University Medical Center
New York, NY 10032
Principal Investigator: Margaret Chen, MD

New York
Weill Cornell Medicine
New York, NY 10065
Principal Investigator: Rache Simmons, MD

Ohio
Cincinnati Breast Surgeons Inc.
Cincinnati, Ohio, 45227
Principal Investigator: Karen S Columbus, MD

Pennsylvania
Thomas Jefferson University
Philadelphia, PA 19107
Principal Investigator: Alexander Sevrukov, MD

Tennessee
The West Clinic
Germantown, TN 38138
Principal Investigator: Richard Fine, MD

Texas
Complete Breast Care
Plano, TX 75075
Principal Investigator: Beth Anglin, MD FACS

Wisconsin
Wheaton Franciscan Healthcare-Franklin Hospital
Franklin, WI 53132
Principal Investigator: Jodi Brehm, MD

 

You can read more about the trial by clicking here. To contact any of these facilities, please visit our Find Treatment page.